Matrix metalloproteinase control of capillary morphogenesis.

  title={Matrix metalloproteinase control of capillary morphogenesis.},
  author={Cyrus M Ghajar and Steven George and Andrew J Putnam},
  journal={Critical reviews in eukaryotic gene expression},
  volume={18 3},
Matrix metalloproteinases (MMPs) play crucial roles in a variety of normal (e.g., blood vessel formation, bone development) and pathophysiological (e.g., wound healing, cancer) processes. This is not only due to their ability to degrade the surrounding extracellular matrix (ECM), but also because MMPs function to reveal cryptic matrix binding sites, release matrix-bound growth factors inherent to these processes, and activate a variety of cell surface molecules. The process of blood vessel… CONTINUE READING


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