Matrix metalloproteinase activity is required for activity-induced angiogenesis in rat skeletal muscle.

@article{Haas2000MatrixMA,
  title={Matrix metalloproteinase activity is required for activity-induced angiogenesis in rat skeletal muscle.},
  author={Tara L. Haas and Małgorzata Milkiewicz and Sandra Davis and Alan Liang Zhou and Stuart Egginton and M. D. Brown and Joseph A. Madri and Olga Hudlick{\'a}},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2000},
  volume={279 4},
  pages={
          H1540-7
        }
}
Proteolysis of the capillary basement membrane is a hallmark of inflammation-mediated angiogenesis, but it is undetermined whether proteolysis plays a critical role in the process of activity-induced angiogenesis. Matrix metalloproteinases (MMPs) constitute the major class of proteases responsible for degradation of basement membrane proteins. We observed significant elevations of mRNA and protein levels of both MMP-2 and membrane type 1 (MT1)-MMP (2.9 +/- 0.7- and 1.5 +/- 0.1-fold above… 
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
Understanding the roles of MMPs and TIMPs may lead to the development of new drug‐related treatments for various muscle disorders based on suppression or upregulation of their expression.
Tissue inhibitor of metalloproteinase-2(TIMP-2)-deficient mice display motor deficits.
TLDR
It is demonstrated that TIMP-2 is expressed by both spinal motor neurons and skeletal muscle, and the tissue specificity of the nerve branching phenotype suggests the involvement of different MMPs and/or extracellular matrix molecules underlying the TIMp-2(-/-) motor phenotype.
The Matrix Metalloproteinase and Tissue Inhibitors of Metalloproteinase Balance in Physiological and Pathological Remodeling of Skeletal Muscles
Skeletal muscle is a highly plastic tissue that undergoes physiological or pathological remodeling in response to various stimuli such as exercise, immobilization, injury, disease, or aging. This
Matrix metalloproteinases and angiogenesis
  • C. Jackson
  • Biology, Medicine
    Current opinion in nephrology and hypertension
  • 2002
TLDR
These multiple regulatory pathways permit fine control over cell invasion during angiogenesis and provide new, precise strategies for targeting abnormal angiogenic, through control of matrix metalloproteinase activity.
Regulation of Proteolysis in Vascular Remodeling
The extracellular matrix (ECM) is the scaffolding on which cells adhere and is comprised of fibrous proteins (such as collagens and elastin), proteoglycans, and water. Matrix–cell adhesion provides
Nitric oxide, VEGF, and VEGFR-2: interactions in activity-induced angiogenesis in rat skeletal muscle.
TLDR
It is concluded that, in stimulated muscles, NO, generated by activation of neuronal NOS by muscle activity or endothelial Nos by increased blood flow and capillary shear stress, may increase capillary proliferation in the early stages of stimulation through upregulation of VEGFR-2 and VEGF.
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