Matrix metalloproteinase activity is required for activity-induced angiogenesis in rat skeletal muscle.

  title={Matrix metalloproteinase activity is required for activity-induced angiogenesis in rat skeletal muscle.},
  author={Tara L. Haas and Małgorzata Milkiewicz and Sandra J. Davis and Alan Liang Zhou and Stuart Egginton and M. D. Brown and Joseph A. Madri and Olga Hudlick{\'a}},
  journal={American journal of physiology. Heart and circulatory physiology},
  volume={279 4},
Proteolysis of the capillary basement membrane is a hallmark of inflammation-mediated angiogenesis, but it is undetermined whether proteolysis plays a critical role in the process of activity-induced angiogenesis. Matrix metalloproteinases (MMPs) constitute the major class of proteases responsible for degradation of basement membrane proteins. We observed significant elevations of mRNA and protein levels of both MMP-2 and membrane type 1 (MT1)-MMP (2.9 +/- 0.7- and 1.5 +/- 0.1-fold above… 

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