Matrix metalloproteinase-activated anthrax lethal toxin inhibits endothelial invasion and neovasculature formation during in vitro morphogenesis.

@article{Alfano2009MatrixMA,
  title={Matrix metalloproteinase-activated anthrax lethal toxin inhibits endothelial invasion and neovasculature formation during in vitro morphogenesis.},
  author={Randall W Alfano and Stephen H Leppla and Shihui Liu and Thomas H Bugge and Cynthia Meininger and Terry C. Lairmore and Arlynn Faye Mulne and Samuel H Davis and Nicholas S. Duesbery and Arthur Edward Frankel},
  journal={Molecular cancer research : MCR},
  year={2009},
  volume={7 4},
  pages={452-61}
}
Solid tumor growth is dependent on angiogenesis, the formation of neovasculature from existing vessels. Endothelial activation of the extracellular signal-regulated kinase 1/2, c-jun NH(2)-terminal kinase, and p38 mitogen-activated protein kinase pathways is central to this process, and thus presents an attractive target for the development of angiogenesis… CONTINUE READING