Matrix metalloproteinase-9, transforming growth factor-β1, and tumor necrosis factor-α plasma levels in chronic pancreatitis.

Abstract

OBJECTIVE The aim of the study was to investigate the plasma levels of matrix metalloproteinase-9 (MMP-9), transforming growth factor-β 1 (TGF-β1), and tumor necrosis factor-α (TNF-α) in chronic pancreatitis (CP). METHODS Blood samples were obtained from 71 patients with CP and 100 control subjects, and plasma levels of MMP-9, TGF-β1, and TNF-α were determined by enzyme-linked immunosorbent assay. RESULTS The plasma levels of MMP-9 (18.3 ± 3.0 ng/mL, p < 0.0001), TGF-β1 (215.4 ± 178.1 ng/mL, p = 0.0301), and TNF-α (111.2 ± 69.3 ng/mL, p < 0.001) were significantly elevated in CP compared to the control group. CONCLUSION The role of elevated plasma MMP-9, TGF-β1, and TNF-α in CP requires further evaluation.

DOI: 10.1007/s12664-012-0299-5
010020030020162017
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@article{Manjari2013MatrixMT, title={Matrix metalloproteinase-9, transforming growth factor-β1, and tumor necrosis factor-α plasma levels in chronic pancreatitis.}, author={K. Sri Manjari and Akka Jyothy and Abbagani Vidyasagar and Boddu Prabhakar and Prathibha Nallari and Ananthapur Venkateshwari}, journal={Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology}, year={2013}, volume={32 2}, pages={103-7} }