Chronic Pancreatitis: Current Status and Challenges for Prevention and Treatment
OBJECTIVE The aim of the study was to investigate the plasma levels of matrix metalloproteinase-9 (MMP-9), transforming growth factor-β 1 (TGF-β1), and tumor necrosis factor-α (TNF-α) in chronic pancreatitis (CP). METHODS Blood samples were obtained from 71 patients with CP and 100 control subjects, and plasma levels of MMP-9, TGF-β1, and TNF-α were determined by enzyme-linked immunosorbent assay. RESULTS The plasma levels of MMP-9 (18.3 ± 3.0 ng/mL, p < 0.0001), TGF-β1 (215.4 ± 178.1 ng/mL, p = 0.0301), and TNF-α (111.2 ± 69.3 ng/mL, p < 0.001) were significantly elevated in CP compared to the control group. CONCLUSION The role of elevated plasma MMP-9, TGF-β1, and TNF-α in CP requires further evaluation.