Matrix metalloproteinase-9-mediated tissue injury overrides the protective effect of matrix metalloproteinase-2 during colitis.

@article{Garg2009MatrixMT,
  title={Matrix metalloproteinase-9-mediated tissue injury overrides the protective effect of matrix metalloproteinase-2 during colitis.},
  author={Pallavi Garg and Matam Vijay-Kumar and Lixin Wang and Andrew T. Gewirtz and Didier Merlin and Shanthi V. Sitaraman},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2009},
  volume={296 2},
  pages={G175-84}
}
Matrix metalloproteinases (MMP) play an important role in pathogenesis of inflammatory bowel disease (IBD). Two known gelatinases, MMP-2 and MMP-9, are upregulated during IBD. Epithelial-derived MMP-9 is an important mediator of tissue injury in colitis, whereas MMP-2 protects against tissue damage and maintains gut barrier function. It has been suggested that developing strategies to block MMP-9 activity in the gut might be of benefit to IBD. However, given that MMP-2 and MMP-9 are… CONTINUE READING