Matrix metalloproteinase-9 measured in urine from bladder cancer patients is an independent prognostic marker of poor survival.

@article{Offersen2010MatrixMM,
  title={Matrix metalloproteinase-9 measured in urine from bladder cancer patients is an independent prognostic marker of poor survival.},
  author={Birgitte Vrou Offersen and Marianne Marquard Knap and Michael Robert Horsman and Jan M Verheijen and Roeland Hanemaaijer and Jens Overgaard},
  journal={Acta oncologica},
  year={2010},
  volume={49 8},
  pages={1283-7}
}
INTRODUCTION Matrix metalloproteinase 9 (MMP-9) is an endopeptidase involved in various cellular processes, such as tumour development and metastatic spread. In biological samples, MMP-9 can occur as pro-MMP-9 and active MMP-9, or these factors complexed with the inhibitor TIMP-1. An assay, which can measure active and total MMP-9 in biological samples, has been used on the urine from bladder cancer patients and demonstrated a significant correlation between MMP-9 and clinical parameters. The… CONTINUE READING

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