Matrix metalloproteinase-9 gene polymorphism in hepatocellular carcinoma patients with hepatitis B and C viruses.

@article{Samanoudy2014MatrixMG,
  title={Matrix metalloproteinase-9 gene polymorphism in hepatocellular carcinoma patients with hepatitis B and C viruses.},
  author={A Z El Samanoudy and Rehan Monir and Ahmed Abouelkhair Badawy and Lamiaa Abdel Rahman Ibrahim and Kamel Farag and S El Baz and Dhaifallah A. Alenizi and Awwad K. A. Alenezy},
  journal={Genetics and molecular research : GMR},
  year={2014},
  volume={13 3},
  pages={
          8025-34
        }
}
Hepatocellular carcinoma (HCC) is the fifth most common malignancy worldwide. In Egypt, the incidence of HCC has doubled over the last decade. Matrix metalloproteinase-9 (MMP-9) plays a key role in cancer invasion and metastasis by degrading the extracellular matrix and basement membrane barriers. A cytosine (C)/thymidine (T) single nucleotide polymorphism at position -1562 in the MMP-9 promoter is reported to influence the expression of the MMP-9 gene. The association between MMP-9 gene… CONTINUE READING

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