Matrix metalloproteinase-9 gene deletion facilitates angiogenesis after myocardial infarction.

@article{Lindsey2006MatrixMG,
  title={Matrix metalloproteinase-9 gene deletion facilitates angiogenesis after myocardial infarction.},
  author={Merry L. Lindsey and Gladys Patricia Escobar and Lawrence W. Dobrucki and Danielle K Goshorn and Shenikqua Bouges and Joseph T. Mingoia and David Mcclister and Haili Su and Joseph C. Gannon and Catherine Macgillivray and Richard T Lee and Albert J. Sinusas and Francis G. Spinale},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2006},
  volume={290 1},
  pages={
          H232-9
        }
}
  • Merry L. Lindsey, Gladys Patricia Escobar, +10 authors Francis G. Spinale
  • Published in
    American journal of…
    2006
  • Medicine, Biology
  • Matrix metalloproteinases (MMPs) are postulated to be necessary for neovascularization during wound healing. MMP-9 deletion alters remodeling postmyocardial infarction (post-MI), but whether and to what degree MMP-9 affects neovascularization post-MI is unknown. Neovascularization was evaluated in wild-type (WT; n = 63) and MMP-9 null (n = 55) mice at 7-days post-MI. Despite similar infarct sizes, MMP-9 deletion improved left ventricular function as evaluated by hemodynamic analysis. Blood… CONTINUE READING

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