Matrix metalloproteinase-9-dependent exposure of a cryptic migratory control site in collagen is required before retinal angiogenesis.

@article{Hangai2002MatrixME,
  title={Matrix metalloproteinase-9-dependent exposure of a cryptic migratory control site in collagen is required before retinal angiogenesis.},
  author={Masanori Hangai and Norihiko Kitaya and Jingsong Xu and Candy K Chan and Jenny Jane Kim and Zena Werb and Stephen J. Ryan and P. C. Brooks},
  journal={The American journal of pathology},
  year={2002},
  volume={161 4},
  pages={1429-37}
}
Retinal neovascularization is a leading cause of human blindness. However, little is known concerning the molecular mechanisms controlling retinal neovascularization in vivo. Here we provide evidence that exposure of a collagen type IV cryptic epitope detected by monoclonal antibody (mAb) HUIV26, delineates sites of vascular bud formation and represents one of the earliest structural remodeling events required before vessel out-growth. Exposure of these cryptic sites was inhibited in matrix… CONTINUE READING
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