Matrix metalloproteinase-9 cooperates with transcription factor Snail to induce epithelial-mesenchymal transition.

@article{Lin2011MatrixMC,
  title={Matrix metalloproteinase-9 cooperates with transcription factor Snail to induce epithelial-mesenchymal transition.},
  author={Chun-Yu Lin and Pei-Hsun Tsai and Chithan C. Kandaswami and P H Lee and Chang-Jen Huang and J J Hwang and M Lee},
  journal={Cancer science},
  year={2011},
  volume={102 4},
  pages={815-27}
}
One of the most fundamental biological processes in tumor metastasis is the process of epithelial-mesenchymal transition (EMT). During EMT, zinc-finger-family of transcription factors such as Snail, Slug and Twist, and matrix metalloproteinases (MMPs) are upregulated, and this correlates with increased tumor cell invasion and motility. We previously obtained a highly invasive A431-III tumor subline, which is a rich source of MMP-9 and observed a plausible link between MMP levels and the… CONTINUE READING