Matrix metalloproteinase-9 −1562 C/T gene polymorphism in Serbian patients with multiple sclerosis

@article{Zivkovic2007MatrixM,
  title={Matrix metalloproteinase-9 −1562 C/T gene polymorphism in Serbian patients with multiple sclerosis},
  author={Maja Zivkovic and Tamara Djuric and Evica Din{\vc}i{\'c} and Ranko Rai{\vc}evi{\'c} and Aleksandra Stankovi{\'c}},
  journal={Journal of Neuroimmunology},
  year={2007},
  volume={189},
  pages={147-150}
}
Matrix metalloproteinase-9 (MMP-9) is suggested to play a role in MS by mediating T cell migration across subendothelial basement membrane and by contribution to myelin breakdown. We studied the association of MMP-9 -1562 C/T gene polymorphisms with MS susceptibility and severity in 187 patients from Serbia. The significant decrease in T allele carriership (p = 0.01), was found in female MS patients. In addition, a trend toward lower MSSS in T allele carriers was noticed (CC, mean 5.7 +/- 2.5… CONTINUE READING