Matrix metalloproteinase-9 (MMP-9) expression in childhood osseous osteosarcoma.

  title={Matrix metalloproteinase-9 (MMP-9) expression in childhood osseous osteosarcoma.},
  author={Bruce P. Himelstein and Naoki Asada and Matthew Carlton and Margaret H. Collins},
  journal={Medical and pediatric oncology},
  volume={31 6},
BACKGROUND Over 80% of patients with osteosarcoma treated with excision alone develop pulmonary metastases, suggesting that the majority of patients with this disease harbor "micrometastases" at diagnosis. There are no histologic or molecular variables which can predict the presence or absence of micrometastasis. Matrix metalloproteinases (MMPs) are a class of matrix- and basement membrane-degrading enzymes whose expression is associated with tumor cell invasive and metastatic behavior. One of… CONTINUE READING


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