Matrix metalloproteinase-9/gelatinase B is required for process outgrowth by oligodendrocytes.

@article{Oh1999MatrixMB,
  title={Matrix metalloproteinase-9/gelatinase B is required for process outgrowth by oligodendrocytes.},
  author={Luke Y S Oh and Peter Hj\orringgaard Larsen and Craig A. Krekoski and Dylan R W Edwards and Frances Donovan and Zena Werb and V. Wee Yong},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1999},
  volume={19 19},
  pages={8464-75}
}
Oligodendrocytes (OLs) extend processes to contact axons as a prerequisite step in myelin formation. As the OL processes migrate toward their axonal targets, they modify adhesion to their substrate, an event that may be regulated by matrix metalloproteinases (MMPs). In the mouse optic nerve, MMP-9/gelatinase B increases during myelin formation. Although tissue inhibitor of metalloproteinase (TIMP)-3 also increases in parallel, the developing optic nerve has focally active MMPs demonstrable by… CONTINUE READING

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Matrix metalloproteinases and diseases of the CNS

  • VW Yong, CA Krekoski, PA Forsyth, R Bell, DR Edwards
  • Trends Neurosci
  • 1998
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