Matrix metalloproteinase-8 functions as a metastasis suppressor through modulation of tumor cell adhesion and invasion.

@article{GutirrezFernndez2008MatrixMF,
  title={Matrix metalloproteinase-8 functions as a metastasis suppressor through modulation of tumor cell adhesion and invasion.},
  author={Ana Guti{\'e}rrez-Fern{\'a}ndez and Antonio Fueyo and Alicia R. Folgueras and Cecilia Garabaya and Caroline J. Pennington and Simon Pilgrim and Dylan R W Edwards and Deborah L. Holliday and J. Louise Jones and Paul N Span and Fred C G J Sweep and Xose S. Puente and Carlos L{\'o}pez-Ot{\'i}n},
  journal={Cancer research},
  year={2008},
  volume={68 8},
  pages={2755-63}
}
Collagenase-2 (matrix metalloproteinase-8, MMP-8) is an MMP mainly produced by neutrophils and associated with many inflammatory conditions. We have previously described that MMP-8 plays a protective role in cancer through its ability to regulate the inflammatory response induced by carcinogens. Moreover, it has been reported that experimental manipulation of the expression levels of this enzyme alters the metastatic behavior of human breast cancer cells. In this work, we have used mutant mice… CONTINUE READING