Matrix metalloproteinase-3 serum levels are correlated with disease activity and predict clinical response in rheumatoid arthritis.

@article{Ribbens2000MatrixMS,
  title={Matrix metalloproteinase-3 serum levels are correlated with disease activity and predict clinical response in rheumatoid arthritis.},
  author={Clio Ribbens and B{\'e}atrice Andr{\'e} and J. M. Jaspar and Olivier Kaye and Mark J. Kaiser and Donat de Groote and Michel Malaise},
  journal={The Journal of rheumatology},
  year={2000},
  volume={27 4},
  pages={888-93}
}
OBJECTIVE To demonstrate that serum matrix metalloproteinase-3 (MMP-3) is a variable associated with disease activity and with the response to treatment in rheumatoid arthritis (RA). METHODS Serum MMP-3 levels were measured and compared to biological and clinical disease activity variables in 20 patients with active RA assessed serially during a one year prospective open label trial with methotrexate or tenidap. RESULTS MMP-3 levels were significantly correlated with C-reactive protein (CRP… CONTINUE READING

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