Matrix metalloproteinase-3: a novel signaling proteinase from apoptotic neuronal cells that activates microglia.

@article{Kim2005MatrixMA,
  title={Matrix metalloproteinase-3: a novel signaling proteinase from apoptotic neuronal cells that activates microglia.},
  author={Yoon Seong Kim and Sung Soo Kim and Jeong Je Cho and Dong Hee Choi and Onyou Hwang and Dong Hoon Shin and Hong Sung Chun and Myron Flint Beal and Tong H. Joh},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2005},
  volume={25 14},
  pages={3701-11}
}
Microglial activation and inflammation are associated with progressive neuronal apoptosis in neurodegenerative human brain disorders. We sought to investigate molecular signaling mechanisms that govern activation of microglia in apoptotic neuronal degeneration. We report here that the active form of matrix metalloproteinase-3 (MMP-3) was released into the serum-deprived media (SDM) of PC12 cells and other media of apoptotic neuronal cells within 2-6 h of treatment of the cells, and SDM and… CONTINUE READING

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Apoptotic

  • K Lauber, E Bohn, +13 authors S Wesselborg
  • CELLS
  • 2003
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