Matrix metalloproteinase 2 promotes cell growth and invasion in colorectal cancer.

@article{Dong2011MatrixM2,
  title={Matrix metalloproteinase 2 promotes cell growth and invasion in colorectal cancer.},
  author={Wei Dong and Hong Li and Yan Zhang and Heng Yin Yang and Mingquan Guo and Li Li and Tongjun Liu},
  journal={Acta biochimica et biophysica Sinica},
  year={2011},
  volume={43 11},
  pages={
          840-8
        }
}
Colorectal cancer (CRC) is the third leading cause of cancer-related death in the western world. In this study, we evaluated the expression of matrix metalloproteinase 2 gene (MMP2) in CRC and analyzed its correlation with clinicopathological features. We found that the expression of MMP2 was significantly higher in CRC tissues than in the colorectal tissues. In addition, high levels of MMP2 protein were positively correlated with the status of tumor size, lymph node metastasis, distant… 
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References

SHOWING 1-10 OF 40 REFERENCES
Prognostic significance of the immunoexpression of matrix metalloproteinase MMP2 and its inhibitor TIMP2 in laryngeal cancer.
TLDR
The results suggest that MMP2 expression may be of prognostic importance in laryngeal cancer, however, imbalances in the extracellular activities of matrix metalloproteinases and tissue inhibitors of matrix meetingallop proteinases, linked to pathological tissue destruction, are more complex and need further investigation.
Prognostic value of membrane type 1 and 2 matrix metalloproteinase expression and gelatinase A activity in bladder cancer.
TLDR
MMP-2 activity is associated with an increase in MT2-M MP expression and with lymph node metastasis and no association was found between MT1-MMP expression and lymph nodes metastasis.
Matrix metalloproteinase–1 is associated with poor prognosis in colorectal cancer
TLDR
It is found that the presence of MMP–1 in colorectal cancer is associated with a poor prognosis and has prognostic value independent of Dukes stage, and treatment of those individuals whose colon tumors produce M MP–1 with MMP inhibitors is a therapeutic strategy worth pursuing.
Overexpression of matrix metalloproteinase 2 predicts unfavorable outcome in early-stage non-small cell lung cancer.
  • B. Passlick, W. Sienel, +4 authors K. Pantel
  • Biology, Medicine
    Clinical cancer research : an official journal of the American Association for Cancer Research
  • 2000
TLDR
The present study revealed that MMP-2 overexpression predicts a poor prognosis in early-stage NSCLC, and it might be worth investigating the role of MMP inhibitors as adjuvant therapeutic agents inNSCLC.
Expression of MMP-2 correlates with increased angiogenesis in CNS metastasis of lung carcinoma.
TLDR
MMP-2 expression appears to confer enhanced vascular proliferation particularly at the brain-tumor interface which would support the contention of enhanced capability of growth and invasion within the CNS, possibly modulated by MMP2.
NGX6 inhibits AP-1 and Ets-1 expression and down-regulates cyclin D1 in human colorectal cancer.
TLDR
It is proposed that NGX6 expression is lost in the multistep process of human colorectal carcinogenesis, which can inhibit the expression of transcription factors AP-1 and Ets-1, and down-regulate the transcriptional activity of the cyclin D1 promoter in human CRC.
Matrix Metalloproteinase/Tissue Inhibitors of Matrix Metalloproteinase Phenotype Identifies Poor Prognosis Colorectal Cancers
TLDR
This study has identified that the MMP/TIMP profile is an independent indicator of poor prognosis in colorectal cancer.
Membrane-type-1 matrix metalloproteinase, matrix metalloproteinase 2, and tissue inhibitor of matrix proteinase 2 in prostate cancer: identification of patients with poor prognosis by immunohistochemistry.
Prognostic value of matrix metalloproteinases (MMP-2 and MMP-9) in patients with lymph node-negative breast carcinoma
TLDR
It is concluded that M MP-2 and MMP-2 are unfavorable prognostic factors in breast cancer patients and might be potential predictive factor for adjuvant systemic therapy.
Increased expression of matrix metalloproteinases 2 and 9 and tissue inhibitors of metalloproteinases 1 and 2 correlate with poor prognostic variables in renal cell carcinoma.
TLDR
Increased expression of MMP2, MMP9, TIMP1, and TIMP2 proteins in RCCs correlate with poor prognostic variables including shortened patient survival, and the paradoxical poor prognosis implication of TIMP overexpression complements the recently documented dual function of TIMPs and warrants further investigation.
...
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