Matrix metalloproteinase-2 cleavage of adrenomedullin produces a vasoconstrictor out of a vasodilator.

@article{Martinez2004MatrixMC,
  title={Matrix metalloproteinase-2 cleavage of adrenomedullin produces a vasoconstrictor out of a vasodilator.},
  author={A. Preite Martinez and Hae-Ryong Oh and Edward J Unsworth and Claudia Bregonzio and J M Saavedra and William G Stetler-Stevenson and Frank Cuttitta},
  journal={The Biochemical journal},
  year={2004},
  volume={383 Pt. 3},
  pages={413-8}
}
MMPs (matrix metalloproteinases) play a major role in the pathogenesis of hypertension by altering the extracellular matrix during cardiovascular remodelling. In the present study we show that MMP-2, but not MMP-9, cleaves the vasodilator peptide AM (adrenomedullin). Addition of the AM-binding protein, complement factor H, prevents this cleavage, providing a hitherto unknown mechanism of action for this binding protein. We identified the signature cleavage fragments and found some of them in… CONTINUE READING

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