Matrix metalloproteinase 2 attenuates brain tumour growth, while promoting macrophage recruitment and vascular repair.

@article{Tremblay2011MatrixM2,
  title={Matrix metalloproteinase 2 attenuates brain tumour growth, while promoting macrophage recruitment and vascular repair.},
  author={Pierrot Tremblay and M J Beaudet and {\`E}ve Tremblay and Naika Rueda and Tina P. Thomas and Luc Valli{\`e}res},
  journal={The Journal of pathology},
  year={2011},
  volume={224 2},
  pages={222-33}
}
Matrix metalloproteinase 2 (MMP2) is an extracellular protein-degrading enzyme widely believed to be involved in the invasion of brain tumour cells. However, this assumption is mainly based on in vitro studies. By characterizing the transcriptome and in vivo properties of 20 astrocytoma cell lines, we found that the levels of MMP2 were higher in GFAP(-) astrocytoma cells and correlated with their ability to induce vascular changes, a common complication of malignant tumours. To study the… CONTINUE READING
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