Matrix metalloproteinase 2 and 9 expression correlated with cavernous sinus invasion of pituitary adenomas.

@article{Liu2005MatrixM2,
  title={Matrix metalloproteinase 2 and 9 expression correlated with cavernous sinus invasion of pituitary adenomas.},
  author={Weiping Liu and Yoshihito Matsumoto and Masaki Okada and Keisuke Miyake and Katsuzo Kunishio and Nobuyuki Kawai and Takashi Tamiya and Seigo Nagao},
  journal={The journal of medical investigation : JMI},
  year={2005},
  volume={52 3-4},
  pages={151-8}
}
OBJECT Matrix metalloproteinase (MMP) 2 and 9 are important for tissue breakdown in the process of tumor invasion. The aim of this study is to evaluate the relationship between the expression of MMP-2, MMP-9, MIB-1 LI and cavernous sinus invasion in pituitary adenomas. METHODS Tissue samples from 54 patients with pituitary adenomas were studied. Expression of MMP-2, MMP-9, and MIB-1 labeling index (LI) were evaluated by immunohistochemical method. In sixteen cases, the expression of MMP-2 and… CONTINUE READING

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