Matrix metalloproteinase-2 and -9 are activated in joint diseases.

@article{Clegg1999MatrixMA,
  title={Matrix metalloproteinase-2 and -9 are activated in joint diseases.},
  author={Peter David Clegg and Stuart D. Carter},
  journal={Equine veterinary journal},
  year={1999},
  volume={31 4},
  pages={
          324-30
        }
}
A study was performed to identify the activation status of the gelatinase MMPs, MMP-2 and -9, in both normal and diseased equine articular tissues. In addition, the production and activation status of equine MMP-2 and -9 by equine articular cells and tissues in response to increasing IL-1beta concentrations was assessed. The study was performed to test the hypothesis that activation of MMPs is a fundamental step in the pathogenesis of joint diseases; and that this activation is mediated by the… CONTINUE READING

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