Matrix metalloproteinase-2 (MMP-2) regulates astrocyte motility in connection with the actin cytoskeleton and integrins.

@article{Ogier2006MatrixM,
  title={Matrix metalloproteinase-2 (MMP-2) regulates astrocyte motility in connection with the actin cytoskeleton and integrins.},
  author={Crystel Ogier and Anne Rose Bernard and A. Chollet and Thierry Le Diguardher and Stephen Hanessian and G{\'e}rard Charton and Michel Khrestchatisky and Santiago Rivera},
  journal={Glia},
  year={2006},
  volume={54 4},
  pages={272-84}
}
Matrix Metalloproteinases (MMPs) play a role in migration of many cell types outside the central nervous system (CNS). Among neural cells, astrocytes are one of the main sources of MMPs in physiological and postlesional conditions. However, no data are available on the possible role of MMPs in astrocyte motility. Using an in vitro model of 2D migration and broad spectrum and selective MMP inhibitors, the authors demonstrated that MMP-2, but not MMP-9, is a key enzyme for astrocyte migration. In… CONTINUE READING
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