Matrix metalloproteinase-2: the forgotten enzyme in aneurysm pathogenesis.

  title={Matrix metalloproteinase-2: the forgotten enzyme in aneurysm pathogenesis.},
  author={Matthew M. Thompson and Gillian Cockerill},
  journal={Annals of the New York Academy of Sciences},
The pathogenesis of abdominal aortic aneurysm (AAAs) involves progressive cycles of proteolysis and inflammation, the product of proteolysis driving subsequent inflammation. Little is yet known about the initiating events. We review the specific literature examining the possibility that MMP-2 may be the initial catalyst. Histologically, elastolysis is one of the earliest observable events in aneurysm genesis. Matrix metalloproteinase-2 (MMP-2), as the dominant gelatinase differentially… CONTINUE READING

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