Matrix metalloproteinase-2, -9, and -12 gene polymorphisms in generalized aggressive periodontitis.

@article{Grkan2007MatrixM,
  title={Matrix metalloproteinase-2, -9, and -12 gene polymorphisms in generalized aggressive periodontitis.},
  author={A. G{\"u}rkan and G. Emingil and B. Saygan and G. Atilla and S. Çinarcik and T. K{\"o}se and A. Berdeli},
  journal={Journal of periodontology},
  year={2007},
  volume={78 12},
  pages={
          2338-47
        }
}
BACKGROUND Matrix metalloproteinases (MMPs) are involved in periodontal tissue remodeling and degradation. Polymorphisms in the promoter region of the MMP-2 and -9 genes and in the coding region of the MMP-12 gene could affect transcription and the function of these enzymes. The aim of the present study was to determine the association between the aforementioned MMP polymorphisms and generalized aggressive periodontitis (GAgP). METHODS Genomic DNA was obtained from the peripheral blood of 92… Expand
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