Matrix metalloproteinase 19 regulates insulin-like growth factor-mediated proliferation, migration, and adhesion in human keratinocytes through proteolysis of insulin-like growth factor binding protein-3.

@article{Sadowski2003MatrixM1,
  title={Matrix metalloproteinase 19 regulates insulin-like growth factor-mediated proliferation, migration, and adhesion in human keratinocytes through proteolysis of insulin-like growth factor binding protein-3.},
  author={Thorsten Sadowski and Sebastian Dietrich and Felix Koschinsky and Radislav Sedlacek},
  journal={Molecular biology of the cell},
  year={2003},
  volume={14 11},
  pages={
          4569-80
        }
}
Unlike most other matrix metalloproteinases (MMPs) MMP-19 is expressed in undifferentiated basal keratinocytes of healthy human skin. The human keratinocyte cell line HaCaT, which like basal keratinocytes constitutively expresses MMP-19, down-regulated the expression of MMP-19 at high calcium concentrations. Calcium-regulation occurred through E-cadherin mediated cell-cell contacts because neutralizing anti-E-cadherin antibodies restored MMP-19 expression in high calcium. Overexpression of MMP… CONTINUE READING

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References

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MMP-19 expression in normal and diseased skin: dysregulation by epidermal proliferation

T. Sadowski, S. Dietrich, +5 authors R. Sedlacek
  • J. Investig. Dermatol
  • 2003
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL

Epilysin (MMP-28) expression is associated with cell proliferation during epithelial repair.

  • The Journal of investigative dermatology
  • 2002
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL