Matrix metalloproteinase 17 is necessary for cartilage aggrecan degradation in an inflammatory environment.

Abstract

OBJECTIVE Aggrecan is a critical component of cartilage extracellular matrix. Several members of the 'a disintegrin and metalloproteinase with thrombospondin motifs' (ADAMTS) family have been characterised as aggrecanases by their ability to generate fragments containing the NITEGE neoepitope from aggrecan. Increased NITEGE fragments in synovial fluid and… (More)
DOI: 10.1136/ard.2010.130757

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Cite this paper

@article{Clements2011MatrixM1, title={Matrix metalloproteinase 17 is necessary for cartilage aggrecan degradation in an inflammatory environment.}, author={Kristen M Clements and Jo K Flannelly and Jonathan Tart and Sarah M V Brockbank and John A Wardale and J J P Freeth and Andrew Parker and Peter Newham}, journal={Annals of the rheumatic diseases}, year={2011}, volume={70 4}, pages={683-9} }