Matrix metalloproteinase-14 mediates a phenotypic shift in the airways to increase mucin production.

@article{Deshmukh2009MatrixMM,
  title={Matrix metalloproteinase-14 mediates a phenotypic shift in the airways to increase mucin production.},
  author={Hitesh S. Deshmukh and Anne McLachlan and Jeffrey J Atkinson and William D Hardie and Thomas R. Korfhagen and Maggie Dietsch and Yang Liu and Peter Y. P. Di and Scott C. Wesselkamper and Michael T. Borchers and George D. Leikauf},
  journal={American journal of respiratory and critical care medicine},
  year={2009},
  volume={180 9},
  pages={834-45}
}
RATIONALE Induced mainly by cigarette smoking, chronic obstructive pulmonary disease (COPD) is a global public health problem characterized by progressive difficulty in breathing and increased mucin production. Previously, we reported that acrolein levels found in COPD sputum could activate matrix metalloproteinase-9 (MMP9). OBJECTIVES To determine whether acrolein increases expression and activity of MMP14, a critical membrane-bound endopeptidase that can initial a MMP-activation cascade… CONTINUE READING