Matrix metalloproteinase 13 modulates intestinal epithelial barrier integrity in inflammatory diseases by activating TNF

@inproceedings{Vandenbroucke2013MatrixM1,
  title={Matrix metalloproteinase 13 modulates intestinal epithelial barrier integrity in inflammatory diseases by activating TNF},
  author={Roosmarijn E. Vandenbroucke and Eline Dejonckheere and Filip Van Hauwermeiren and Sofie Lodens and Riet De Rycke and Elien Van Wonterghem and An Staes and Kris Gevaert and Carlos L{\'o}pez-Ot{\'i}n and Claude Libert},
  booktitle={EMBO molecular medicine},
  year={2013}
}
Several pathological processes, such as sepsis and inflammatory bowel disease (IBD), are associated with impairment of intestinal epithelial barrier. Here, we investigated the role of matrix metalloproteinase MMP13 in these diseases. We observed that MMP13(-/-) mice display a strong protection in LPS- and caecal ligation and puncture-induced sepsis. We could attribute this protection to reduced LPS-induced goblet cell depletion, endoplasmic reticulum stress, permeability and tight junction… CONTINUE READING

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