Matrix metalloproteinase-12 expression correlates with local recurrence and metastatic disease in non-small cell lung cancer patients.

@article{Hofmann2005MatrixME,
  title={Matrix metalloproteinase-12 expression correlates with local recurrence and metastatic disease in non-small cell lung cancer patients.},
  author={H S Hofmann and Gesine Hansen and G{\"u}nther Richter and Christiane Taege and Andreas Simm and R. -E. Silber and Stefan E. G. Burdach},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2005},
  volume={11 3},
  pages={1086-92}
}
PURPOSE Non-small cell lung cancer (NSCLC) is a very common and aggressive malignancy. Survival after resection of tumor is especially determined by the occurrence of distant metastasis. Matrix metalloproteinases (MMP) support this metastatic process by degradation of the extracellular matrix. EXPERIMENTAL DESIGN We used DNA microarray technology to examine the expression of 22 MMPs in 89 surgically treated NSCLC patients. Validation of microarray results was done using reverse transcription… CONTINUE READING

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Randomized placebocontrolled trials of the matrix metalloproteinase inhibitor (MMPI), BAY12-9566 as adjuvant therapy for patients with small cell and nonsmall cell lung cancer

  • JR Rigas, CA Denham, DA Rinaldi
  • Proc Am Soc Clin Oncol 2003;22:628
  • 2003
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