Matrix metalloproteinase-12 deficiency ameliorates the clinical course and demyelination in Theiler’s murine encephalomyelitis

@article{Hansmann2012MatrixMD,
  title={Matrix metalloproteinase-12 deficiency ameliorates the clinical course and demyelination in Theiler’s murine encephalomyelitis},
  author={Florian Hansmann and Vanessa Herder and Arno Kalkuhl and Verena Haist and Ning Zhang and Dirk Schaudien and Ulrich Deschl and Wolfgang Baumgaertner and Reiner G Ulrich},
  journal={Acta Neuropathologica},
  year={2012},
  volume={124},
  pages={127-142}
}
Matrix metalloproteinases (MMPs) are a family of extracellular proteases involved in the pathogenesis of demyelinating diseases like multiple sclerosis (MS). The aim of the present study was to investigate whether MMPs induce direct myelin degradation, leukocyte infiltration, disruption of the blood–brain barrier (BBB), and/or extracellular matrix… CONTINUE READING