Matrix metalloproteinase-12 (MMP-12) in osteoclasts: new lesson on the involvement of MMPs in bone resorption.

@article{Hou2004MatrixM,
  title={Matrix metalloproteinase-12 (MMP-12) in osteoclasts: new lesson on the involvement of MMPs in bone resorption.},
  author={Peng Hou and Tine Troen and Maria C Ovejero and Tove Kirkegaard and Thomas Lykke Andersen and Inger Byrjalsen and Mercedes Ferreras and Takuya Sato and Steven D Shapiro and Niels T{\ae}kker Foged and Jean-Marie Delaiss{\'e}},
  journal={Bone},
  year={2004},
  volume={34 1},
  pages={37-47}
}
Osteoclasts require matrix metalloproteinase (MMP) activity and cathepsin K to resorb bone, but the critical MMP has not been identified. Osteoclasts express MMP-9 and MMP-14, which do not appear limiting for resorption, and the expression of additional MMPs is not clear. MMP-12, also called metalloelastase, is reported only in a few cells, including tissue macrophages and hypertrophic chondrocytes. MMP-12 is critical for invasion and destruction in pathologies such as aneurysm and emphysema… CONTINUE READING
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