Matrix metalloproteinase 1 in pre-eclampsia and fetal growth restriction: reduced gene expression in decidual tissue and protein expression in extravillous trophoblasts.

@article{Lian2010MatrixM1,
  title={Matrix metalloproteinase 1 in pre-eclampsia and fetal growth restriction: reduced gene expression in decidual tissue and protein expression in extravillous trophoblasts.},
  author={Ingrid Alsos Lian and Johanne Holm Toft and Guro Dalheim Olsen and Mette Langaas and Line Bj\orge and Irina Poliakova Eide and Per E B\ordahl and Rigmor Austgulen},
  journal={Placenta},
  year={2010},
  volume={31 7},
  pages={615-20}
}
Superficial invasion of extravillous trophoblasts (EVTs) and impaired spiral artery remodelling are characterizing phenomena in pregnancies complicated by pre-eclampsia (PE) and fetal growth restriction (FGR). However, the underlying causes remain unclear. In this study, gene expression in decidua basalis tissue from pregnancies complicated with PE and/or FGR (n = 18) and normal pregnancies (n = 17) was assessed by Affymetrix HG Focus microarray to obtain hints of mechanisms involved in the… CONTINUE READING

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