Matrix metalloproteinase 1 (MMP1) is associated with early-onset lung cancer.

  title={Matrix metalloproteinase 1 (MMP1) is associated with early-onset lung cancer.},
  author={Wiebke Sauter and Albert Rosenberger and Lars Beckmann and Silke Kropp and Kirstin Mittelstrass and Maria N Timofeeva and Gabriele Woelke and Angelika Steinwachs and Daniela Scheiner and Eckart Meese and Gerhard Sybrecht and Florian Kronenberg and Hendrik C Dienemann and Jenny Chang-Claude and Thomas Illig and Heinz-Erich Wichmann and H. Bickeb{\"o}ller and Angela Risch},
  journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  volume={17 5},
Matrix metalloproteinases (MMP) play a key role in the breakdown of extracellular matrix and in inflammatory processes. MMP1 is the most highly expressed interstitial collagenase degrading fibrillar collagens. Overexpression of MMP1 has been shown in tumor tissues and has been suggested to be associated with tumor invasion and metastasis. Nine haplotype tagging and additional two intronic single nucleotide polymorphisms (SNP) of MMP1 were genotyped in a case control sample, consisting of 635… CONTINUE READING