Matrix metalloproteinase, hyaluronidase and elastase inhibitory potential of standardized extract of Centella asiatica

@article{Nema2013MatrixMH,
  title={Matrix metalloproteinase, hyaluronidase and elastase inhibitory potential of standardized extract of Centella asiatica},
  author={Neelesh Kumar Nema and Niladri Maity and Birendra K. Sarkar and Pulok Kumar Mukherjee},
  journal={Pharmaceutical Biology},
  year={2013},
  volume={51},
  pages={1182 - 1187}
}
Abstract Context: Centella asiatica (L.) Urban (Apiaceae), a valuable herb described in Ayurveda, is used in the indigenous system of medicine as a tonic to treat skin diseases. Objective: Centella asiatica methanol extract and its ethyl acetate, n-butanol and aqueous fraction, were subjected for the evaluation of skin care potential through the in vitro hyaluronidase, elastase and matrix metalloproteinase-1 (MMP-1) inhibitory assay. Materials and methods: The C. asiatica plant was extracted… 
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References

SHOWING 1-10 OF 31 REFERENCES
Standardized Clitoria ternatea leaf extract as hyaluronidase, elastase and matrix-metalloproteinase-1 inhibitor
TLDR
The experiment validated the traditional uses of C. ternatea and may be recommended for use in the treatment of different types of skin wounds, where taraxerol may be a responsible biomarker.
Exploring Tagetes erecta Linn flower for the elastase, hyaluronidase and MMP-1 inhibitory activity.
Anti‐elastase and anti‐hyaluronidase of phenolic substance from Areca catechu as a new anti‐ageing agent
TLDR
This phenolic substance from A. catechu effectively inhibited hyaluronidase activity and showed more potent activity than that of reference compounds, oleanolic acid and ursolic acid.
Triterpenes from Centella asiatica stimulate extracellular matrix accumulation in rat experimental wounds.
TLDR
The 3 purified components of TECA were all able to reproduce the effects of the complete drug, with some differences depending on the product, which showed an increased remodeling of the collagen matrix in the wound.
Cucumis sativus fruit-potential antioxidant, anti-hyaluronidase, and anti-elastase agent
TLDR
CSLJ is the rich source of ascorbic acid and this study thereby rationalizes the use of C. sativus as potential anti-wrinkle agent in cosmetic products.
Inhibitory Effects of Herbal Medicines on Hyaluronidase Activity
TLDR
Among the solvent-fractionated extracts, the butanol fractions of Acantbopanax gracilistylus and Glycyrrhiza uralensis with 1 mg/ml as the final concentration exhibited more than 50% of inhibition on hyaluronidase activity, and the other fractions with the same concentration did less than 20%.
Enhancement of the skin-protective activities of Centella asiatica L. Urban by a nano-encapsulation process.
Preparation of Ursane Triterpenoids from Centella asiatica Using High Speed Countercurrent Chromatography with Step‐Gradient Elution
Abstract Pentacyclic triterpene aglycones and glycosides of the ursane type were successfully separated from 600 mg of a polar extract from Centella asiatica (Apiaceae) by high speed countercurrent
Asiaticoside induction for cell‐cycle progression, proliferation and collagen synthesis in human dermal fibroblasts
TLDR
Fifty‐four genes, with known functions for cell proliferation, cell‐cycle progression and synthesis of the extracellular matrix, were significantly up‐regulated in the “whole‐genes nest” expression profile at various timepoints and there is a close correlation among the gene profile, mRNA and protein production in the cells response to asiaticoside stimulation.
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