Matrix metalloprotease triggered bioresponsive drug delivery systems - Design, synthesis and application.

@article{Nultsch2018MatrixMT,
  title={Matrix metalloprotease triggered bioresponsive drug delivery systems - Design, synthesis and application.},
  author={Kira Helga Maria Nultsch and Oliver Germershaus},
  journal={European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V},
  year={2018},
  volume={131},
  pages={
          189-202
        }
}
Engineering of drug delivery systems has evolved in recent decades from comparably simple designs that merely controlled drug release to complex, often multistage systems that respond to multiple biological or environmental stimuli. Matrix metalloproteases (MMPs) are a family of proteolytic enzymes that are involved in numerous physiologic and pathophysiologic processes, including cancer. Therefore, these enzymes represent highly relevant targets for the development of novel bioresponsive drug… CONTINUE READING
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