Matrix metalloprotease-9 inhibition improves amyloid beta-mediated cognitive impairment and neurotoxicity in mice.

@article{Mizoguchi2009MatrixMI,
  title={Matrix metalloprotease-9 inhibition improves amyloid beta-mediated cognitive impairment and neurotoxicity in mice.},
  author={Hiroyuki Mizoguchi and Kazuhiro Takuma and Emiko Fukuzaki and Daisuke Ibi and Eiichi Someya and Ko-hei Akazawa and Tursun Alkam and Hiroko Tsunekawa and Akihiro Mouri and Yukihiro Noda and Toshitaka Nabeshima and Kiyofumi Yamada},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2009},
  volume={331 1},
  pages={14-22}
}
In Alzheimer's disease (AD), the expression of matrix metalloproteases (MMPs), which are capable of degrading extracellular matrix proteins, is increased in the brain. Previous studies with cultured glial cells have demonstrated that amyloid beta (Abeta) protein can induce the expression of MMPs, which could be involved in the degradation of Abeta. In the present study, we investigated the role of MMP-2 and MMP-9 in cognitive impairment induced by the injection of Abeta in mice. The… CONTINUE READING