Matrix loss and synthesis following a single impact load on articular cartilage in vitro.

@article{Jeffrey1997MatrixLA,
  title={Matrix loss and synthesis following a single impact load on articular cartilage in vitro.},
  author={Janet E Jeffrey and Linda A Thomson and Richard M Aspden},
  journal={Biochimica et biophysica acta},
  year={1997},
  volume={1334 2-3},
  pages={223-32}
}
Articular cartilage biopsies were subjected to a single impact load and the metabolic response of the chondrocytes investigated using radiolabelled precursors for protein ([3H]leucine) and glycosaminoglycan ([35S]sulfate). The severity of the impact was controlled by using different masses and drop heights in a purpose built drop tower. Loss of matrix components was studied by prelabelling prior to loading, the possible repair response by pulse labelling at defined intervals after loading… CONTINUE READING
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