Matrix implanted laser desorption ionization (MILDI) combined with ion mobility-mass spectrometry for bio-surface analysis.

@article{Tempez2005MatrixIL,
  title={Matrix implanted laser desorption ionization (MILDI) combined with ion mobility-mass spectrometry for bio-surface analysis.},
  author={Agn{\`e}s Tempez and Michael V. Ugarov and Tom Egan and J. Albert Schultz and Alexey Novikov and Serge Della-Negra and Yvon Lebeyec and Mich{\`e}le Pautrat and Martine Caroff and Vincent S. Smentkowski and Hoau-Yan Wang and Shelley N Jackson and Amina S Woods},
  journal={Journal of proteome research},
  year={2005},
  volume={4 2},
  pages={540-5}
}
The implantation of low velocity massive gold cluster ions allows homogeneous incorporation of a metallic matrix into the near-surface region of rat brain tissues. Subsequent analysis by laser desorption ionization mass spectrometry yields spectra exhibiting molecular ion peaks in the mass range up to 35 kDa similar to those observed by matrix-assisted LDI. Matrix-implanted LDI when combined with ion-mobility preseparation promises to be a useful technique for molecular imaging of biotissues… CONTINUE READING