Matrix imbalance by inducing expression of metalloproteinase and oxidative stress in cochlea of hyperhomocysteinemic mice

@article{Kundu2009MatrixIB,
  title={Matrix imbalance by inducing expression of metalloproteinase and oxidative stress in cochlea of hyperhomocysteinemic mice},
  author={Soumi Kundu and Neetu Tyagi and Utpal Sen and Suresh C Tyagi},
  journal={Molecular and Cellular Biochemistry},
  year={2009},
  volume={332},
  pages={215-224}
}
Clinical study reports hearing loss in patients with low folic acid (FA) and elevated homocysteine (Hcy). We hypothesize that elevated Hcy induces imbalance in matrix turnover and oxidative stress in cochlea. Cystathione β-synthase heterozygous knockout mice were used as model for hyperhomocysteinemia. Matrix remodeling induced by Hcy resulted from elevated MMP-2, -9, and -14. MMP-2 and -9 showed elevated gelatinase activity in CBS (+/−) cochlea. Tissue inhibitors of matrix metalloproteinase… CONTINUE READING

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