Matrix effects: the Achilles heel of quantitative high-performance liquid chromatography-electrospray-tandem mass spectrometry.

@article{Taylor2005MatrixET,
  title={Matrix effects: the Achilles heel of quantitative high-performance liquid chromatography-electrospray-tandem mass spectrometry.},
  author={P. J. Taylor},
  journal={Clinical biochemistry},
  year={2005},
  volume={38 4},
  pages={328-34}
}
High-performance liquid chromatography coupled by an electrospray ion source to a tandem mass spectrometer (HPLC-ESI-MS/MS) is the current analytical method of choice for quantitation of analytes in biological matrices. With HPLC-ESI-MS/MS having the characteristics of high selectivity, sensitivity, and throughput, this technology is being increasingly used in the clinical laboratory. An important issue to be addressed in method development, validation, and routine use of HPLC-ESI-MS/MS is… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 201 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 39 references

A high-throughput HPLC–mass spectrometry method suitable for the TDM of cyclosporin [abstract

  • PJ Taylor, SV Lynch, PI. Pillans
  • Ther Drug Monit 2003;25:506
  • 2003
1 Excerpt

Similar Papers

Loading similar papers…