Matrix effect in bio-analysis of illicit drugs with LC-MS/MS: Influence of ionization type, sample preparation, and biofluid

@article{Dams2003MatrixEI,
  title={Matrix effect in bio-analysis of illicit drugs with LC-MS/MS: Influence of ionization type, sample preparation, and biofluid},
  author={Riet Dams and Marilyn A Huestis and Willy E E Lambert and Constance M. Murphy},
  journal={Journal of the American Society for Mass Spectrometry},
  year={2003},
  volume={14},
  pages={1290-1294}
}
The purpose of the present work was to evaluate the synergistic effect of ionization type, sample preparation technique, and bio-fluid on the presence of matrix effect in quantitative liquid chromatography (LC)-MS/MS analysis of illicit drugs by post-column infusion experiments with morphine (10-µg/mL solution). Three bio-fluids (urine, oral fluid, and plasma) were pretreated with four sample preparation procedures [direct injection, dilution, protein precipitation, solid-phase extraction (SPE… CONTINUE READING
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