Matrix-degrading podosomes in smooth muscle cells.

  title={Matrix-degrading podosomes in smooth muscle cells.},
  author={Thomas Lener and Gerald Burgstaller and Luca Crimaldi and Sibylle Lach and Mario Gimona},
  journal={European journal of cell biology},
  volume={85 3-4},
Activation of protein kinase C by phorbol esters triggers the remodelling of the actin cytoskeleton and the formation of podosomes in smooth muscle cells (SMCs). Regional control of actin dynamics at specialised microdomains results in a local reduction in contractile forces. The molecular basis for this local inhibition of contractility includes the clustering of cortactin during podosome formation (which precedes the rapid, local dispersion of myosin, tropomyosin and h1 calponin), and the… CONTINUE READING
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