Matrix-degrading metalloproteinases in tumor progression.

  title={Matrix-degrading metalloproteinases in tumor progression.},
  author={Lynn M Matrisian and J H Wright and Ken J. Newell and J P Witty},
  journal={Princess Takamatsu symposia},
The matrix-degrading metalloproteinases (MMPs) have been implicated in tumor invasion and metastasis. Recently it has become clear that the expression of MMPs in tumors is frequently localized to stromal cells surrounding malignant tumor cells. In the mouse skin model of multi-stage carcinogenesis, the MMP stromelysin is expressed in stromal fibroblast-like cells surrounding benign and malignant squamous cell carcinomas. Conversion of these tumors to highly invasive and metastatic spindle-cell… CONTINUE READING


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