Matrix contraction by dermal fibroblasts requires transforming growth factor-beta/activin-linked kinase 5, heparan sulfate-containing proteoglycans, and MEK/ERK: insights into pathological scarring in chronic fibrotic disease.

@article{Chen2005MatrixCB,
  title={Matrix contraction by dermal fibroblasts requires transforming growth factor-beta/activin-linked kinase 5, heparan sulfate-containing proteoglycans, and MEK/ERK: insights into pathological scarring in chronic fibrotic disease.},
  author={Yunliang Chen and Xu Shi-wen and Jonathan P van Beek and Laura A Kennedy and Marilyn McLeod and Elisabetta A Renzoni and George Bou-Gharios and Sarah A. Wilcox-Adelman and Paul F. Goetinck and Mark Eastwood and Carol Mary Black and David J. Abraham and Andrew Leask},
  journal={The American journal of pathology},
  year={2005},
  volume={167 6},
  pages={1699-711}
}
Scarring is characterized by excessive synthesis and contraction of extracellular matrix. Here, we show that fibroblasts from scarred (lesional) areas of patients with the chronic fibrotic disorder diffuse scleroderma [diffuse systemic sclerosis (dSSc)] show an enhanced ability to adhere to and contract extracellular matrix, relative to fibroblasts from unscarred (nonlesional) areas of dSSc patients and dermal fibroblasts from normal, healthy individuals. The contractile abilities of normal and… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 64 extracted citations

Similar Papers

Loading similar papers…