Matrix-bound thrombospondin promotes angiogenesis in vitro

  title={Matrix-bound thrombospondin promotes angiogenesis in vitro},
  author={Roberto Francesco Nicosia and George P. Tuszynski},
  journal={The Journal of Cell Biology},
  pages={183 - 193}
Thrombospondin (TSP) is a multidomain adhesive protein postulated to play an important role in the biological activity of the extracellular matrix. To test this hypothesis, TSP-containing fibrin and collagen matrices were evaluated for their capacity to support angiogenesis and cell growth from explants of rat aorta. This serum-free model allowed us to study the angiogenic effect of TSP without the interference of attachment and growth factors present in serum. TSP promoted dose-dependent… CONTINUE READING


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