Matrix-attachment regions can impart position-independent regulation of a tissue-specific gene in transgenic mice.

@article{McKnight1992MatrixattachmentRC,
  title={Matrix-attachment regions can impart position-independent regulation of a tissue-specific gene in transgenic mice.},
  author={Robert A McKnight and Avi Shamay and Lavanya Sankaran and Robert J. Wall and Lothar Hennighausen},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1992},
  volume={89 15},
  pages={6943-7}
}
Matrix-attachment regions (MARs) may function as domain boundaries and partition chromosomes into independently regulated units. We have tested whether MAR sequences from the chicken lysozyme locus, the so-called A-elements, can confer position-independent regulation to a whey acidic protein (WAP) transgene in mammary tissue of mice. In the absence of MARs, expression of WAP transgenes was observed in 50% of the lines, and regulation during pregnancy, during lactation, and upon hormonal… CONTINUE READING