Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry combined with magnetic beads for detecting serum protein biomarkers in parkinson's disease.

@article{Li2011MatrixassistedLD,
  title={Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry combined with magnetic beads for detecting serum protein biomarkers in parkinson's disease.},
  author={Yao-hua Li and Jian Wang and Xiao-li Zheng and Yan-li Zhang and Xinhai Li and Shun Yu and Xin He and Piu Chan},
  journal={European neurology},
  year={2011},
  volume={65 2},
  pages={105-11}
}
BACKGROUND Biomarkers for neurodegenerative diseases are essential to facilitate disease diagnosis. Application of proteomics has greatly hastened the search for novel biomarkers. In this study, new potential biomarkers were discovered, and a diagnostic pattern was established for idiopathic Parkinson's disease (PD) by using proteomic technology. METHODS Serum proteins from PD patients and controls were captured by magnetic bead-based weak cation exchange. The molecular weight of the proteins… CONTINUE READING
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