Matrix-assisted laser desorption/ionization mass spectra reflect solution-phase zinc finger peptide complexation.

@article{Lehmann1999MatrixassistedLD,
  title={Matrix-assisted laser desorption/ionization mass spectra reflect solution-phase zinc finger peptide complexation.},
  author={Edda Lehmann and Renato Zenobi and Susanne Vetter},
  journal={Journal of the American Society for Mass Spectrometry},
  year={1999},
  volume={10 1},
  pages={27-34}
}
The complexation between an 18-residue zinc finger peptide of CCHC type (CCHC = Cys-X2-Cys-X4-His-X4-Cys, X = variable amino acid) from the gag protein p55 of human immunodeficiency virus type 1 (HIV-1) and various transition metal ions was studied by means of circular dichroism spectroscopy and matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS). A correlation between the complexation behavior in solution and in MALDI-MS could be established. It was shown that MALDI-MS is… CONTINUE READING