Matrix assembly, regulation, and survival functions of laminin and its receptors in embryonic stem cell differentiation

@article{Li2002MatrixAR,
  title={Matrix assembly, regulation, and survival functions of laminin and its receptors in embryonic stem cell differentiation},
  author={Shaohua Li and David Harrison and Salvatore Carbonetto and Reinhard F{\"a}ssler and Neil Smyth and David Edgar and Peter D Yurchenco},
  journal={The Journal of Cell Biology},
  year={2002},
  volume={157},
  pages={1279 - 1290}
}
Laminin-1 is essential for early embryonic basement membrane assembly and differentiation. Several steps can be distinguished, i.e., the expression of laminin and companion matrix components, their accumulation on the cell surface and assembly into basement membrane between endoderm and inner cell mass, and the ensuing differentiation of epiblast. In this study, we used differentiating embryoid bodies derived from mouse embryonic stem cells null for gamma1-laminin, beta1-integrin and alpha/beta… CONTINUE READING

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