Matrix Remodeling Promotes Pulmonary Hypertension through Feedback Mechanoactivation of the YAP/TAZ-miR-130/301 Circuit.

@article{Bertero2015MatrixRP,
  title={Matrix Remodeling Promotes Pulmonary Hypertension through Feedback Mechanoactivation of the YAP/TAZ-miR-130/301 Circuit.},
  author={Thomas Bertero and Katherine A. Cottrill and Yu Lu and Christina Mallarino Haeger and Paul B. Dieffenbach and Sofia Annis and Andrew Hale and B. Shyamasundara Bhat and Vivek Kaimal and Y Y Zhang and Brian B Graham and Rahul Kumar and Rajan Saggar and Rajeev Saggar and William Dean Wallace and David J. Ross and S. M. Black and Sohrab Fratz and Jeffrey R. Fineman and Sara O. Vargas and Kathleen J. Haley and Aaron B Waxman and B. Nelson Chau and Laura E Fredenburgh and Stephen Y Chan},
  journal={Cell reports},
  year={2015},
  volume={13 5},
  pages={1016-32}
}
Pulmonary hypertension (PH) is a deadly vascular disease with enigmatic molecular origins. We found that vascular extracellular matrix (ECM) remodeling and stiffening are early and pervasive processes that promote PH. In multiple pulmonary vascular cell types, such ECM stiffening induced the microRNA-130/301 family via activation of the co-transcription factors YAP and TAZ. MicroRNA-130/301 controlled a PPAR?-APOE-LRP8 axis, promoting collagen deposition and LOX-dependent remodeling and further… CONTINUE READING
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